Journal Articles since 2003

1. Neuhaus P., Oustanina S., Loch T., Krüger M, Bober E., Dono R., Zeller R. and Braun T. (2003). Reduced mobility of FGF-mutant myoblasts might contribute to dystrophic changes in the musculature of FGF2/FGF6/mdx triple mouse mutants. Mol. Cell. Biol. 23, 6037-6048.

2. Deller T., Korte M., Chabanis S., Drakew A., Schwegler H., Good-Stefani G., Zuniga A., Schwarz K., Bonhoeffer T., Zeller R*., Frotscher M.* and Mundel P.* (2003). Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity. (*joint senior authors). Proc. Natl Acad Sci USA 100,10494-10499.

3. Galli A., Roure A., Zeller R. and Dono R. (2003). Glypican-4 modulates FGF signalling and regulates dorso-ventral forebrain patterning in Xenopus embryos. Development 30, 4919-4929.

4. Sturm, J., Keese, M., Zhang, H., Bönninghoff, R., Magdeburg, R., Vajkoczy, P., Post, S., Dono, R., Zeller, R. and Gretz, N. (2004). Liver regeneration in FGF-2-deficient mice: VEGF acts as potential functional substitute for FGF-2. Liver Int. 24, 161-168.

5. Michos O., Panman L., Vintersten K., Beier K., Zeller R. and Zuniga A. (2004). Gremlin mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development 131, 3401-3410.

6. Zuniga A, Michos O., Spitz F., Haramis A.P.G., Panman L., Vintersten K., Klasen C., Mansfield W., Kuc S., Duboule D., Dono R. and Zeller R. (2004). Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression. Genes Dev. 18, 1553-1564.

7. Panman L., Drenth T., te Welscher P., Zuniga A. and Zeller R. (2005). Genetic interaction of Gli3 and Alx4 during limb development. Int. J. Dev. Bio. 49, 443-448.

8. Panman L., Galli A., Lagarde N., Michos O., Soete G., Zuniga A. and Zeller R. (2006). Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and Gremlin1/FGF-mediated epithelial-mesenchymal signalling. Development 133, 3419-3428.

9. Vaillant C., Michos O., Brellier F., Orolicki S., Taieb S., Moreno E., Te H., Zeller R. and Monard D. (2007). Protease Nexin-1 and its receptor LRP modulate SHH signalling during cerebellar development. Development 134, 1745-1754.

10. Michos O., Gonçalves A., Lopez-Rios J., Tiecke E., Naillat F., Beier K., Galli A., Vainio S. and Zeller, R. (2007). Reduction of BMP4 activity by Gremlin1 enables ureteric bud outgrowth and GDNF/Wnt11 feedback signalling during kidney branching morphogenesis. Development 134, 2397-2405.

11. Paparidis, Z., Abbasi, A.A., Malik, S., Goode D.K., Callaway, H., Elgar, G., de Graaff, E., Lopez-Rios, J., Zeller, R. and Grzeschik, K-H. (2007). An ultraconserved non-coding sequence element controls a subset of spatiotemporal GLI3 expression. Dev. Growth Diff. 49, 543-553.

12. Bénazet J.D, Bischofberger M., Tiecke E., Gonçalves A, Martin J.F., Zuniga A., Naef F. and Zeller R. (2009). A Self-Regulatory System of Interlinked Signaling Feedback Loops Controls Mouse Limb Patterning. Science 323, 1050-1053.

13. Galli A., Robay D., Osterwalder M., Bao X., Bénazet J.D., Tariq M., Paro R., Mackem S. and Zeller R. (2010). Distinct Roles of Hand2 in Initiating Polarity and Posterior Shh Expression during the Onset of Mouse Limb Bud Development. PLoS Genetics 6, e1000901.

14. Scotti C., Tonnarelli B., Papadimitropoulos A., Scherberich A., Schaeren S., Schauerte A., Lopez-Rios J., Zeller R., Barbero A. and Martin I. (2010). Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering. Proc. Natl. Acad. Sci. USA 107, 7251–7256.

15. Fujimori S., Novak H., Weissenböck M., Jussila M., Gonçalves A., Zeller R., Galloway J., Thesleff I. and Hartmann C. (2010). Wnt/β-catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4. Dev. Biol. 348, 97-106.

16. Osterwalder M., Galli A., Rosen B., Skarnes W.C., Zeller R.* and Lopez-Rios J.* (2010, *joint senior authors). Dual RMCE permits high-throughput re-engineering of mutant alleles in mouse ES cells. Nature Methods 7, 893-895.

17. Probst S., Kraemer C., Demougin P., Sheth R., Martin G.R., Shiratori H., Hamada H., Iber D., Zeller R. and Zuniga A. (2011) SHH propagates distal limb bud development by enhancing CYP26b1-mediated retinoic acid clearance via AER-FGF signalling. Development 138, 1913-1923.

18. Gonçalves A. and Zeller R. (2011). Genetic Analysis Reveals an Unexpected Role of BMP7 in Initiation of Ureteric Bud Outgrowth in Mouse Embryos. PLoS One 6, e19370.

19. Lopez-Rios J., Speziale D., Robay D., Scotti M., Nusspaumer G., Osterwalder M., Galli A., Holländer G.A., Kmita M. and Zeller R (2012). GLI3 Constrains Digit Number by Controlling Both Progenitor Proliferation and BMP-Dependent Exit to Chondrogenesis. Dev. Cell 22, 837-848.

20. Itou J., 2, Kawakami H., Quach T., Osterwalder M., Evans S., Zeller R. and Kawakami Y. (2012). Islet1 regulates establishment of the posterior hindlimb-field upstream of the Hand2-Shh morpho-regulatory network in the mouse. Development 139, 1620-1629.

21. Zuniga A., Laurent F., Lopez-Rios J., Klasen C. Matt, N. and Zeller R. (2012). Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds. BMC Dev. Biol. 12, 23 doi:10.1186.

22. Bénazet J.D., Pignatti E., Nugent A., Unal E., Laurent F. and Zeller R. (2012). Smad4 is required to induce digit ray primordia and to initiate the aggregation and differentiation of chondrogenic progenitors in mouse limb buds. Development 139, 4250-4260.

23. Probst S., Zeller R. and Zuniga A. (2013). The hedgehog target Vlk genetically interacts with Gli3 to regulate chondrocyte differentiation during mouse long bone development. Differentiation 85, 121-130.

24. Benazet J.D. and Zeller R. (2013). Dual Requirement of Ectodermal Smad4 During AER Formation and Termination of Feedback Signaling in Mouse Limb Buds. Genesis 51, 660–666.

25. Lopez-Rios J., Duchesne A., Speziale D., Andrey G., Peterson K.A., Germann P., Ünal E., Liu J., Floriot S., Barbey S., Gallard Y., Müller-Gerbl M., Courtney A.D., Klopp C., Rodriguez S., Ivanek R., Beisel C., Wicking C., Iber D., Robert B., McMahon A.P., Duboule D. and Zeller R. (2014). Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs. Nature 511, 46-51. (Article)

26. Osterwalder M., Speziale D., Shoukry M., Mohan R., Ivanek R., Kohler M., Beisel C., Wen X., Scales S.J., Christoffels V.M., Visel A., Lopez-Rios J., and Zeller R. (2014). HAND2 Targets Define a Network of Transcriptional Regulators that Compartmentalize the Early Limb Bud Mesenchyme. Dev Cell 31, 345–357.

27. Van Dusen N.J., Casanovas J., Vincentz J.W., Firulli B.A., Osterwalder M., Lopez-Rios J., Zeller R., Zhou B., Grego-Bessa J., De La Pompa J.L., Shou W. and Firulli A.B. (2014). Hand2 is an Essential Regulator for Two Notch-Dependent Functions within the Embryonic Endocardium. Cell Reports 9, 2071-2083.

28. Vaillant C., Valdivieso P., Nuciforo S., Kool M., Schwarzentruber-Schauerte A., Méreau H., Cabuy E., Lobrinus J.A., Pfister S., Zuniga A., Frank S. and Zeller R. (2015). Serpine2/PN-1 is required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma. PLoS One 10, e0124870 doi: 10.1371/journal.pone.0124870.

29. Schmitz-Rohmer D., Probst S., Yang Z.Z., Laurent F., Zuniga A., Zeller R., Hynx D., Hemmings B.A. and Hergovich A. (2015). NDR kinases are essential for somitogenesis and cardiac looping during mouse embryonic development. PLoS One (in press).

Reviews and Book Chapters since 2003

1. Panman L. and Zeller R. (2003). Patterning the Limb Before and After SHH Signalling. J. Anatomy 202, 3-12.

2. Zeller R. (2004). It Takes Time to Make a Pinky: Unexpected Insights into How SHH Patterns Vertebrate Digits. Science STKE 259, pe 53.

3. Zuniga A. and Galli A. (2006). Limb Pattern Formation: Upstream and Downstream of Shh Signaling. In: Shh and Gli Signalling in Development (eds. S. Iowie and C.E. Fisher), pp. 79-92. Landes Bioscience

3. Zeller, R. and Zuniga, A. (2007). Shh and Gremlin1 chromosomal landscapes in development and disease. Curr. Op. Genetics Dev. 17, 428-434.

4. Bénazet J.D. and Zeller, R. (2009). Vertebrate Limb Development: Moving from Classical Morphogen Gradients to an Integrated 4-Dimensional Patterning System. Cold Spring Harb Perspect Biol 1, a001339.

5. Affolter, M and Zeller, R. (2009). From Cells to Organs: new insight into organ morphogenesis. Curr. Op. Genetics Dev. 19, 421-423.

6. Affolter M., Zeller R. and Caussinus (2009). Tissue remodelling through branching morphogenesis. Nature Rev. Mol. Cell Biol. 10, 831-842.

7. Zeller R., Lopez-Rios J. and Zuniga A. (2009). Vertebrate limb bud development: moving towards integrative analysis of organogenesis. Nature Reviews Genetics 10, 845-858.

8. Zeller R. (2010). The temporal dynamics of vertebrate limb development, teratogenesis and evolution. Curr. Op. Genetics Dev. 20, 384–390.

9. Zuniga, A. Zeller, R. and Probst, S. (2012). The molecular basis of human congenital limb malformations. WIRE Dev. Biol. 1, 803-822.

10. Iber D. and Zeller R. (2012). Making sense – data-based simulations of vertebrate limb development. Curr. Op. Genetics Dev. 6, 570-577.

11. Tonnarelli B., Centola M., Barbero A., Zeller R. and Martin I. (2014). Re-engineering Development to Instruct Tissue Regeneration. Curr Top Dev Biol. 108, 319-338.

12. Pignatti E., Zeller R. and Zuniga A. (2014). To BMP or not to BMP during vertebrate limb bud development. Sem. Cell Dev. Biol. 32, 119-127.

13. Zuniga A and Zeller R. (2014) In Turing’s hands – the making of digits. Science 345, 516-517.

14. McGrath J.C., McLachlan E.M. and Zeller R. (2015). Transparency in Research involving Animals: The Basel Declaration and new principles for reporting research in BJP manuscripts. Br J Pharmacol. 172, 2427-2432.

Published Protocols since 2003

1. Fischer A.H., Jacobson K.A., Rose J., Lorentz P. and Zeller R. (2010). Preparation of Cells and Tissues for Fluorescence Microscopy. In: Imaging: A Laboratory Manual, Chapter 13 (ed. R. Yuste). CSH Press.

2. Osterwalder M., Lopez-Rios J. and Zeller R. (2010). Next generation engineering of conditional mouse alleles with loxP and FRT sites by dual RMCE. Nature Protocol Exchange, doi:10.1038/protex.2010.210.