DR. JONAS MALKMUS
Postdoctoral Fellow
During my PhD-studies I concern myself with the evolution of the regulatory landscape of Gremlin1.
Gremlin1, a BMP antagonist, facilitates the self-regulation and maintenance of the SHH/GREM1/AER-FGF feedback loop as it is important for the progression of the limb bud outgrowth and formation of the correct number of digits. Gremlin is regulated by cis-regulatory elements located downstream in a large genomic landscape. These elements are highly conserved in vertebrates.
The aim is to understand how these cis-regulatory elements have evolved during evolution and in which kind they may have contributed to the diverse phenotypes of vertebrate appendages.
KEY PUBLICATIONS
Malkmus J., Ramos Martins L., Jhanwar S., Kircher B., Palacio V., Sheth R., Leal F., Duchesne A., Lopez-Rios J., Peterson K., Reinhardt R., Onimaru K., Cohn M., Zuniga A. and Zeller R.
(Nat Commun 12, 5557 (2021). https://doi.org/10.1038/s41467-021-25810-1)