Key Publications

Nature 2014

Lopez-Rios J., et al. 2014

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Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs.

Dev Cell 2014

Osterwalder M., et al. 2014

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HAND2 Targets Define a Network of Transcriptional Regulators that Compartmentalize the Early Limb Bud Mesenchyme.

Zeller Banner images-15

Lopez-Rios J., et al. 2012

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Gli3 constrains Digit Number by Controlling both Progenitor Proliferation and BMP-Dependent Exit to Chrondogenesis.

Dev 2011

Probst S., et al. 2011

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SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signaling.

Nat Meth 2010

Osterwalder M., et al. 2010

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Dual RMCE permits high-throughput re-engineering of mutant alleles in mouse ES cells.

Plos 2010

Galli A., et al. 2010

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Distinct Roles of Hand2 in Initiating Polarity and Posterior Shh Expression during the Onset of Mouse Limb Bud Development

Science 2009

BĂ©nazet J.D., et al. 2009

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A Self-Regulatory System of Interlinked Signaling Feedback Loops Controls Mouse Limb Patterning

Nat Rev 2009

Zeller R., et al. 2009

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Vertebrate limb bud development: moving towards integrative analysis of organogenesis.

GenesDev 2004

Zuniga A., et al. 2004

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Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin Expression.

Science 2002

teWelscher P. et al. 2002

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Progression of Vertebrate Limb Development through SHH-Mediated Counteraction of GLI3

Nature 1999

Zuniga A., et al. 1999

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Signal relay by BMP antagonism controls the SHH/FGF-4 feedback loop in vertebrate limb buds.